DANUGLIPRON

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Synonyms
Status
Molecule Category Free-form
UNII DN9IUI24GP

Structure

InChI Key HYBAKUMPISVZQP-DEOSSOPVSA-N
Smiles N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1
InChI
InChI=1S/C31H30FN5O4/c32-25-14-20(16-33)4-5-23(25)19-41-30-3-1-2-26(35-30)21-8-11-36(12-9-21)18-29-34-27-7-6-22(31(38)39)15-28(27)37(29)17-24-10-13-40-24/h1-7,14-15,21,24H,8-13,17-19H2,(H,38,39)/t24-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C31H30FN5O4
Molecular Weight 555.61
AlogP 4.89
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 9.0
Polar Surface Area 113.5
Molecular species ACID
Aromatic Rings 4.0
Heavy Atoms 41.0

Pharmacology

Mechanism of Action Action Reference
Glucagon-like peptide 1 receptor agonist AGONIST Other Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) Glucagon-like receptor Glucagon-like peptide receptor
12 - - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
12 - - - -

Target Conservation

Protein: Glucagon-like peptide 1 receptor
Description: Glucagon-like peptide 1 receptor
Organism : Homo sapiens
P43220 ENSG00000112164

Cross References

Resources Reference
ChEMBL CHEMBL4518483
FDA SRS DN9IUI24GP
PDB UK4
SureChEMBL SCHEMBL20266351
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