TEREVALEFIM

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Search structure


Synonyms	ANG-3777 Ang-3777 Refanalin SNV-003 Terevalefim
Status
Molecule Category	Free-form
UNII	GG91UXK2M5

Structure


InChI Key	FOHWAQGURRYJFK-ONEGZZNKSA-N
Smiles	C(=C/c1cccs1)\c1cc[nH]n1
InChI	InChI=1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H8N2S
Molecular Weight	176.24
AlogP	2.64
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	28.68
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	12.0

Pharmacology

Mechanism of Action	Action	Reference
Hepatocyte growth factor receptor agonist	AGONIST	PubMed

Target Conservation


Protein: Hepatocyte growth factor receptor Description: Hepatocyte growth factor receptor Organism : Homo sapiens P08581 ENSG00000105976

Cross References

Resources	Reference
ChEMBL	CHEMBL4650326
FDA SRS	GG91UXK2M5

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025