SUVECALTAMIDE

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Synonyms
Status
Molecule Category Free-form
UNII MIA4WMP8QN

Structure

InChI Key IQIKXZMPPBEWAD-CQSZACIVSA-N
Smiles CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1
InChI
InChI=1S/C20H23F3N2O2/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26)/t14-/m1/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H23F3N2O2
Molecular Weight 380.41
AlogP 4.57
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 7.0
Polar Surface Area 51.22
Molecular species NEUTRAL
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Mechanism of Action Action Reference
Voltage-gated T-type calcium channel modulator MODULATOR Other PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Voltage-gated calcium channel
- 1.2-8.2 - - -
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2
- - - - 30
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 1.2-8.2 - - 30

Cross References

Resources Reference
ChEMBL CHEMBL1684950
FDA SRS MIA4WMP8QN
SureChEMBL SCHEMBL1065999
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