ZANDELISIB

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Search structure


Synonyms	ACC-524 ME-401 Me-401 PW-143 PWT-143 PWT143 Pwt-143 Zandelisib
Status
Molecule Category	Free-form
UNII	8Z28M5SX0X

Structure


InChI Key	WPFUFWIHMYZXSF-UHFFFAOYSA-N
Smiles	CN1CCC(c2ccccc2CC(C)(C)Nc2nc(N3CCOCC3)nc(-n3c(C(F)F)nc4ccccc43)n2)CC1
InChI	InChI=1S/C31H38F2N8O/c1-31(2,20-22-8-4-5-9-23(22)21-12-14-39(3)15-13-21)38-28-35-29(40-16-18-42-19-17-40)37-30(36-28)41-25-11-7-6-10-24(25)34-27(41)26(32)33/h4-11,21,26H,12-20H2,1-3H3,(H,35,36,37,38)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C31H38F2N8O
Molecular Weight	576.7
AlogP	5.23
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	84.23
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	42.0

Pharmacology

Mechanism of Action	Action	Reference
PI3-kinase p110-delta subunit inhibitor	INHIBITOR	Other

Target Conservation


Protein: PI3-kinase p110-delta subunit Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Organism : Homo sapiens O00329 ENSG00000171608

Cross References

Resources	Reference
ChEMBL	CHEMBL4650214
FDA SRS	8Z28M5SX0X

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025