SOTALOL HYDROCHLORIDE

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Search structure


Synonyms	Beta-cardone Betapace Betapace af DL-MJ-1999 Darob MJ 1999 MJ-1999 NSC-337251 NSC-760358 Sorine Sotacor Sotalex Sotalol hcl Sotalol hydrochloride Sotylize
Status
Molecule Category	Salt-form
UNII	HEC37C70XX
EPA CompTox	DTXSID8021278

Structure


InChI Key	VIDRYROWYFWGSY-UHFFFAOYSA-N
Smiles	CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1.Cl
InChI	InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C12H21ClN2O3S
Molecular Weight	308.83
AlogP	1.09
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	78.43
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	18.0

Pharmacology

Mechanism of Action	Action	Reference
Beta-1 adrenergic receptor antagonist	ANTAGONIST	DailyMed Wikipedia

Target Conservation


Protein: Beta-2 adrenergic receptor Description: Beta-2 adrenergic receptor Organism : Homo sapiens P07550 ENSG00000169252












Protein: Beta-1 adrenergic receptor Description: Beta-1 adrenergic receptor Organism : Homo sapiens P08588 ENSG00000043591











Protein: HERG Description: Potassium voltage-gated channel subfamily H member 2 Organism : Homo sapiens Q12809 ENSG00000055118

Cross References

Resources	Reference
ChEBI	9207
ChEMBL	CHEMBL1700
FDA SRS	HEC37C70XX
SureChEMBL	SCHEMBL118761

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025