PRIDOPIDINE

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Search structure


Synonyms	ACR-16 ACR16 FR-310826 FR310826 Huntexil Pridopidine
Status
Molecule Category	Free-form
UNII	HD4TW8S2VK
EPA CompTox	DTXSID90188225

Structure


InChI Key	YGKUEOZJFIXDGI-UHFFFAOYSA-N
Smiles	CCCN1CCC(c2cccc(S(C)(=O)=O)c2)CC1
InChI	InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H23NO2S
Molecular Weight	281.42
AlogP	2.68
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	37.38
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	19.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine D2 receptor modulator	MODULATOR	PubMed PubMed Wikipedia

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor	-	-	-	81.7	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	81.7	-

Target Conservation


Protein: Dopamine D2 receptor Description: D(2) dopamine receptor Organism : Homo sapiens P14416 ENSG00000149295

Cross References

Resources	Reference
ChEMBL	CHEMBL596802
DrugBank	DB11947
FDA SRS	HD4TW8S2VK
PharmGKB	PA166115441
SureChEMBL	SCHEMBL166748
ZINC	ZINC000022063703

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025