MESORIDAZINE

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Search structure


Synonyms	Lidanar Mesoridazine NC-123 NSC-186066 Serentil TPS-23 Thioridazine-2-sulfoxide
Status
Molecule Category	Free-form
ATC	N05AC03
UNII	5XE4NWM740
EPA CompTox	DTXSID3023265

Structure


InChI Key	SLVMESMUVMCQIY-UHFFFAOYSA-N
Smiles	CN1CCCCC1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21
InChI	InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C21H26N2OS2
Molecular Weight	386.59
AlogP	4.9
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	4.0
Polar Surface Area	23.55
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	26.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	316.23-549.54	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	316.23-323.59	-	-	-

Cross References

Resources	Reference
ChEBI	6780
ChEMBL	CHEMBL1088
DrugBank	DB00933
DrugCentral	1712
FDA SRS	5XE4NWM740
Human Metabolome Database	HMDB0015068
Guide to Pharmacology	7227
KEGG	C07143
PharmGKB	PA450386
SureChEMBL	SCHEMBL19735

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025