SENICAPOC

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Synonyms
Status
Molecule Category Free-form
UNII TS6G201A6Q
EPA CompTox DTXSID60276906

Structure

InChI Key SCTZUZTYRMOMKT-UHFFFAOYSA-N
Smiles NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
InChI
InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H15F2NO
Molecular Weight 323.34
AlogP 3.78
Hydrogen Bond Acceptor 1.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 4.0
Polar Surface Area 43.09
Molecular species NEUTRAL
Aromatic Rings 3.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Intermediate conductance calcium-activated potassium channel protein 4 blocker BLOCKER PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Calcium-activated potassium channel
- 6-12 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 6-12 - - -

Target Conservation

Protein: Intermediate conductance calcium-activated potassium channel protein 4
Description: Intermediate conductance calcium-activated potassium channel protein 4
Organism : Homo sapiens
O15554 ENSG00000104783

Cross References

Resources Reference
ChEMBL CHEMBL405821
DrugBank DB06280
FDA SRS TS6G201A6Q
Guide to Pharmacology 2331
SureChEMBL SCHEMBL1443805
ZINC ZINC000003816408
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