TARENFLURBIL


Synonyms	E-7869 Flurbiprofen, (r)- Flurizan MPC-7869 R-flurbiprofen Tarenflurbil
Status
Molecule Category	Free-form
UNII	501W00OOWA
EPA CompTox	DTXSID40199508


InChI Key	SYTBZMRGLBWNTM-SNVBAGLBSA-N
Smiles	C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1
InChI	InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1

Mechanism of Action	Action	Reference
Gamma-secretase modulator	MODULATOR	PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	-	-	-	0-48
Enzyme Protease Aspartic protease Aspartic protease AD clan Aspartic protease A22A subfamily Aspartic protease A22A regulatory subfamily	-	-	-	-	23
Enzyme	-	-	-	-	0-48
Ion channel Other ion channel Miscellaneous ion channel Presenilin ER Ca2+ leak channel family	-	-	-	-	23
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Chemokine receptor CXC chemokine receptor	-	-	-	-	20

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	-	20-51
Mus musculus	-	-	-	-	0-48


Protein: Gamma-secretase Description: Presenilin-1 Organism : Homo sapiens P49768 ENSG00000080815











Protein: Gamma-secretase Description: Presenilin-2 Organism : Homo sapiens P49810 ENSG00000143801












Protein: Gamma-secretase Description: Gamma-secretase subunit APH-1B Organism : Homo sapiens Q8WW43 ENSG00000138613











Protein: Gamma-secretase Description: Nicastrin Organism : Homo sapiens Q92542 ENSG00000162736













Protein: Gamma-secretase Description: Gamma-secretase subunit APH-1A Organism : Homo sapiens Q96BI3 ENSG00000117362













Protein: Gamma-secretase Description: Gamma-secretase subunit PEN-2 Organism : Homo sapiens Q9NZ42 ENSG00000205155

CONTENTS