SELPERCATINIB


Synonyms	LOXO-292 LY-3527723 LY3527723 Loxo-292 Ret inhibitor loxo-292 Retevmo Selpercatinib
Status
Molecule Category	Free-form
UNII	CEGM9YBNGD


InChI Key	XIIOFHFUYBLOLW-UHFFFAOYSA-N
Smiles	COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1
InChI	InChI=1S/C29H31N7O3/c1-29(2,37)18-39-24-9-25(28-21(10-30)13-33-36(28)17-24)20-5-6-26(31-12-20)34-15-22-8-23(16-34)35(22)14-19-4-7-27(38-3)32-11-19/h4-7,9,11-13,17,22-23,37H,8,14-16,18H2,1-3H3

Mechanism of Action	Action	Reference
Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Ret family	-	1.24	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1.24	-	-	-


Protein: Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET Description: Proto-oncogene tyrosine-protein kinase receptor Ret Organism : Homo sapiens P07949 ENSG00000165731













Protein: Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET Description: Proto-oncogene tyrosine-protein kinase receptor Ret Organism : Homo sapiens P07949 ENSG00000165731













Protein: Tyrosine-protein kinase receptor RET Description: Proto-oncogene tyrosine-protein kinase receptor Ret Organism : Homo sapiens P07949 ENSG00000165731













Protein: Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET Description: Kinesin-1 heavy chain Organism : Homo sapiens P33176 ENSG00000170759













Protein: Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET Description: Coiled-coil domain-containing protein 6 Organism : Homo sapiens Q16204 ENSG00000108091

CONTENTS