NINTEDANIB ESYLATE


Synonyms	Nintedanib esilate Nintedanib esylate Nintedanib ethanesulfonate Ofev
Status
Molecule Category	Salt-form
UNII	42F62RTZ4G
EPA CompTox	DTXSID40215873


InChI Key	MMMVNAGRWOJNMW-FJBFXRHMSA-N
Smiles	CCS(=O)(=O)O.COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1
InChI	InChI=1S/C31H33N5O4.C2H6O3S/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38;1-2-6(3,4)5/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38);2H2,1H3,(H,3,4,5)/b29-28-;

Mechanism of Action	Action	Reference
Fibroblast growth factor receptor inhibitor	INHIBITOR	FDA

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	37-610	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase PDGFR family	-	59-65	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	13-34	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	13-610	-	-	-
Mus musculus	-	13	-	-	-


Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor beta Organism : Homo sapiens P09619 ENSG00000113721











Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 1 Organism : Homo sapiens P11362 ENSG00000077782












Protein: Platelet-derived growth factor receptor Description: Platelet-derived growth factor receptor alpha Organism : Homo sapiens P16234 ENSG00000134853












Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 1 Organism : Homo sapiens P17948 ENSG00000102755











Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 2 Organism : Homo sapiens P21802 ENSG00000066468












Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 4 Organism : Homo sapiens P22455 ENSG00000160867










Protein: Fibroblast growth factor receptor Description: Fibroblast growth factor receptor 3 Organism : Homo sapiens P22607 ENSG00000068078











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 3 Organism : Homo sapiens P35916 ENSG00000037280











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052

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