SOLCITINIB

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Search structure


Synonyms	G-154578 G154578 GLPG-0778 GLPG-0788 GLPG0778 GSK-2586184 GSK-2586184A GSK2586184A Glpg-0778 Gsk-2586184 Solcitinib
Status
Molecule Category	Free-form
UNII	3V7GQ1260K

Structure


InChI Key	MPYACSQFXVMWNO-UHFFFAOYSA-N
Smiles	CC1(C)CN(C(=O)c2ccc(-c3cccc4nc(NC(=O)C5CC5)nn34)cc2)C1
InChI	InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H23N5O2
Molecular Weight	389.46
AlogP	3.23
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	79.6
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	29.0

Pharmacology

Mechanism of Action	Action	Reference
Tyrosine-protein kinase JAK1 inhibitor	INHIBITOR	Other PubMed

Target Conservation


Protein: Tyrosine-protein kinase JAK1 Description: Tyrosine-protein kinase JAK1 Organism : Homo sapiens P23458 ENSG00000162434

Cross References

Resources	Reference
ChEMBL	CHEMBL3301606
FDA SRS	3V7GQ1260K
Guide to Pharmacology	9697
SureChEMBL	SCHEMBL2240393
ZINC	ZINC000118401631

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025