EcoDrugPlus


Synonyms	Amber acid Dihydrofumaric acid E363 FEMA NO. 4719 NSC-106449 Succinic acid Succinicum acidum
Status
Molecule Category	Free-form
UNII	AB6MNQ6J6L
EPA CompTox	DTXSID6023602

Synonyms

Amber acid

Dihydrofumaric acid

E363

FEMA NO. 4719

NSC-106449

Succinic acid

Succinicum acidum

Status

Molecule Category

Free-form

UNII

AB6MNQ6J6L

EPA CompTox

DTXSID6023602


InChI Key	KDYFGRWQOYBRFD-UHFFFAOYSA-N
Smiles	O=C(O)CCC(=O)O
InChI	InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

InChI Key

KDYFGRWQOYBRFD-UHFFFAOYSA-N

Smiles

O=C(O)CCC(=O)O

InChI

InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)

Property Name	Value
Molecular Formula	C4H6O4
Molecular Weight	118.09
AlogP	-0.06
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	74.6
Molecular species	ACID
Aromatic Rings	0.0
Heavy Atoms	8.0

Property Name

Value

Molecular Formula

C4H6O4

Molecular Weight

118.09

AlogP

-0.06

Hydrogen Bond Acceptor

2.0

Hydrogen Bond Donor

2.0

Number of Rotational Bond

3.0

Polar Surface Area

74.6

Molecular species

ACID

Aromatic Rings

0.0

Heavy Atoms

8.0

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Chlorocebus sabaeus	-	1.3	-	-	-

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Chlorocebus sabaeus

1.3

Resources	Reference
ChEBI	15741
ChEMBL	CHEMBL576
DrugBank	DB00139
DrugCentral	2487
FDA SRS	AB6MNQ6J6L
Human Metabolome Database	HMDB0000254
Guide to Pharmacology	3637
KEGG	C00042
PDB	SIN
SureChEMBL	SCHEMBL829
ZINC	ZINC000000895030

Resources

Reference

ChEBI

ChEMBL

DrugBank

DrugCentral

FDA SRS

Human Metabolome Database

HMDB0000254

Guide to Pharmacology

KEGG

PDB

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

SUCCINIC ACID

Structure

Physicochemical Descriptors

Pharmacology

Cross References