LEVOTHYROXINE SODIUM

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Search structure


Synonyms	Eferox Eltroxin Euthyrox Evotrox L-thyroxine henning Levaxin Levo-t Levolet Levothroid Levothyroid Levothyrox Levothyroxine sodium Levothyroxine sodium anhydrous Levothyroxine sodium hydrate Levoxine
Status
Molecule Category	Salt-form
ATC	H03AA01
UNII	9J765S329G
EPA CompTox	DTXSID10209941

Structure


InChI Key	ANMYAHDLKVNJJO-LTCKWSDVSA-M
Smiles	N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)[O-].O.[Na+]
InChI	InChI=1S/C15H11I4NO4.Na.H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;1H2/q;+1;/p-1/t12-;;/m0../s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H12I4NNaO5
Molecular Weight	816.87
AlogP	4.56
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	5.0
Polar Surface Area	92.78
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	24.0

Pharmacology

Mechanism of Action	Action	Reference
Thyroid hormone receptor agonist	AGONIST	Wikipedia Wikipedia FDA

Cross References

Resources	Reference
CAS NUMBER	6106-07-6
ChEBI	6447
ChEMBL	CHEMBL2103741
FDA SRS	9J765S329G
SureChEMBL	SCHEMBL2327406

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026