AMIODARONE HYDROCHLORIDE

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Search structure


Synonyms	Amidox Amiodar Amiodarone Amiodarone hcl Amiodarone hydrochloride Amyben Cordarone Cordarone x Cordarone x 100 Cordarone x 200 Darmil L-3428 Miodaron NSC-343341 NSC-85442
Status
Molecule Category	Salt-form
UNII	976728SY6Z
EPA CompTox	DTXSID7037185

Structure


InChI Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Smiles	CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1.Cl
InChI	InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H30ClI2NO3
Molecular Weight	681.78
AlogP	6.94
Hydrogen Bond Acceptor	4.0
Number of Rotational Bond	11.0
Polar Surface Area	42.68
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	31.0

Pharmacology

Mechanism of Action	Action	Reference
HERG blocker	BLOCKER	DailyMed Wikipedia Wikipedia Wikipedia Wikipedia

Target Conservation


Protein: HERG Description: Potassium voltage-gated channel subfamily H member 2 Organism : Homo sapiens Q12809 ENSG00000055118

Cross References

Resources	Reference
ChEBI	2664
ChEMBL	CHEMBL1083993
FDA SRS	976728SY6Z
SureChEMBL	SCHEMBL41348

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025