NAPROXEN ETEMESIL

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Search structure


Synonyms	LT-NS001 MX-1094 Naproxen etemesil
Status
Molecule Category	Free-form
UNII	214269U36R
EPA CompTox	DTXSID60191903

Structure


InChI Key	JGBUBSOKFSVXKS-LBPRGKRZSA-N
Smiles	COc1ccc2cc([C@H](C)C(=O)OCCS(C)(=O)=O)ccc2c1
InChI	InChI=1S/C17H20O5S/c1-12(17(18)22-8-9-23(3,19)20)13-4-5-15-11-16(21-2)7-6-14(15)10-13/h4-7,10-12H,8-9H2,1-3H3/t12-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H20O5S
Molecular Weight	336.41
AlogP	2.54
Hydrogen Bond Acceptor	5.0
Number of Rotational Bond	6.0
Polar Surface Area	69.67
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Cross References

Resources	Reference
ChEMBL	CHEMBL2105683
DrugBank	DB12398
FDA SRS	214269U36R
SureChEMBL	SCHEMBL3047558
ZINC	ZINC000034005963

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025