TAZAROTENE


Synonyms	AGN 190168 AGN-190168 Arazlo Avage Fabior Idp-123 Tazarotene Tazorac Zorac
Status
Molecule Category	Free-form
ATC	D05AX05
UNII	81BDR9Y8PS
EPA CompTox	DTXSID5046691


InChI Key	OGQICQVSFDPSEI-UHFFFAOYSA-N
Smiles	CCOC(=O)c1ccc(C#Cc2ccc3c(c2)C(C)(C)CCS3)nc1
InChI	InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3

Mechanism of Action	Action	Reference
Retinoic acid receptor agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group B Nuclear hormone receptor subfamily 1 group B member 1	63	-	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group B Nuclear hormone receptor subfamily 1 group B member 2	0.8	-	-	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group B Nuclear hormone receptor subfamily 1 group B member 3	40	-	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	0.8-63	-	-	-	-


Protein: Retinoic acid receptor Description: Retinoic acid receptor alpha Organism : Homo sapiens P10276 ENSG00000131759












Protein: Retinoic acid receptor Description: Retinoic acid receptor beta Organism : Homo sapiens P10826 ENSG00000077092












Protein: Retinoic acid receptor Description: Retinoic acid receptor gamma Organism : Homo sapiens P13631 ENSG00000172819

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