GLESATINIB


Synonyms	Glesatinib MG-90265 MG-90265X MG90265 MG90265H9 MG90265X MG90265gly MGCD-265 MGCD265 Mgcd-265
Status
Molecule Category	Free-form
UNII	7Q29OXD98N


InChI Key	YRCHYHRCBXNYNU-UHFFFAOYSA-N
Smiles	COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccc(F)cc5)cc4F)c3s2)nc1
InChI	InChI=1S/C31H27F2N5O3S2/c1-40-13-12-34-17-20-4-8-24(36-18-20)28-16-25-30(43-28)27(10-11-35-25)41-26-9-7-22(15-23(26)33)37-31(42)38-29(39)14-19-2-5-21(32)6-3-19/h2-11,15-16,18,34H,12-14,17H2,1H3,(H2,37,38,39,42)

Mechanism of Action	Action	Reference
Hepatocyte growth factor receptor inhibitor	INHIBITOR

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Met family	-	1-29	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	1	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1-29	-	-	-


Protein: Hepatocyte growth factor receptor Description: Hepatocyte growth factor receptor Organism : Homo sapiens P08581 ENSG00000105976











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 1 Organism : Homo sapiens P17948 ENSG00000102755











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 3 Organism : Homo sapiens P35916 ENSG00000037280











Protein: Vascular endothelial growth factor receptor Description: Vascular endothelial growth factor receptor 2 Organism : Homo sapiens P35968 ENSG00000128052












Protein: Tyrosine-protein kinase TIE-2 Description: Angiopoietin-1 receptor Organism : Homo sapiens Q02763 ENSG00000120156












Protein: Macrophage-stimulating protein receptor Description: Macrophage-stimulating protein receptor Organism : Homo sapiens Q04912 ENSG00000164078

CONTENTS