VARESPLADIB METHYL

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Search structure


Synonyms	A-002 LY-333013 LY333013 S-3013 Varespladib methyl Varespladib methyl ester
Status
Molecule Category	Free-form
UNII	0NB98NBX3D

Structure


InChI Key	VJYDOJXJUCJUHL-UHFFFAOYSA-N
Smiles	CCc1c(C(=O)C(N)=O)c2c(OCC(=O)OC)cccc2n1Cc1ccccc1
InChI	InChI=1S/C22H22N2O5/c1-3-15-20(21(26)22(23)27)19-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(19)29-13-18(25)28-2/h4-11H,3,12-13H2,1-2H3,(H2,23,27)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C22H22N2O5
Molecular Weight	394.43
AlogP	2.47
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	100.62
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	29.0

Pharmacology

Mechanism of Action	Action	Reference
Group X secretory phospholipase A2 inhibitor	INHIBITOR	PubMed

Target Conservation


Protein: Group X secretory phospholipase A2 Description: Group 10 secretory phospholipase A2 Organism : Homo sapiens O15496 ENSG00000069764












Protein: Phospholipase A2 group IIA Description: Phospholipase A2, membrane associated Organism : Homo sapiens P14555 ENSG00000188257










Protein: Phospholipase A2 group V Description: Phospholipase A2 group V Organism : Homo sapiens P39877 ENSG00000127472

Cross References

Resources	Reference
ChEMBL	CHEMBL2105659
DrugBank	DB05737
FDA SRS	0NB98NBX3D
SureChEMBL	SCHEMBL25678
ZINC	ZINC000001550156

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025