EcoDrugPlus


Synonyms	Apilimod STA 5326 STA-5326 Sta-5326
Status
Molecule Category	Free-form
UNII	GFW2K84S4L

Synonyms

Apilimod

STA 5326

STA-5326

Sta-5326

Status

Molecule Category

Free-form

UNII

GFW2K84S4L


InChI Key	HSKAZIJJKRAJAV-KOEQRZSOSA-N
Smiles	Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1
InChI	InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+

InChI Key

HSKAZIJJKRAJAV-KOEQRZSOSA-N

Smiles

Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1

InChI

InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+

Property Name	Value
Molecular Formula	C23H26N6O2
Molecular Weight	418.5
AlogP	3.08
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	84.76
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	31.0

Property Name

Value

Molecular Formula

C23H26N6O2

Molecular Weight

418.5

AlogP

3.08

Hydrogen Bond Acceptor

8.0

Hydrogen Bond Donor

1.0

Number of Rotational Bond

8.0

Polar Surface Area

84.76

Molecular species

NEUTRAL

Aromatic Rings

3.0

Heavy Atoms

31.0

Mechanism of Action	Action	Reference
1-phosphatidylinositol 3-phosphate 5-kinase inhibitor	INHIBITOR	PubMed PubMed

Mechanism of Action

Action

Reference

1-phosphatidylinositol 3-phosphate 5-kinase inhibitor

INHIBITOR

PubMed PubMed

Resources	Reference
ChEMBL	CHEMBL4297643
DrugBank	DB05611
FDA SRS	GFW2K84S4L
Guide to Pharmacology	9859
PubChem	10173277
SureChEMBL	SCHEMBL426299
ZINC	ZINC000011726230

Resources

Reference

ChEMBL

CHEMBL4297643

DrugBank

DB05611

FDA SRS

GFW2K84S4L

Guide to Pharmacology

PubChem

SureChEMBL

ZINC

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

APILIMOD

Structure

Physicochemical Descriptors

Pharmacology

Cross References