EcoDrugPlus


Synonyms	APX001 Apx-001 Apx001 E1211 Fosmanogepix
Status
Molecule Category	Free-form
UNII	1XQ871489P

Synonyms

APX001

Apx-001

Apx001

E1211

Fosmanogepix

Status

Molecule Category

Free-form

UNII

1XQ871489P


InChI Key	JQONJQKKVAHONF-UHFFFAOYSA-N
Smiles	Nc1c(-c2cc(Cc3ccc(COc4ccccn4)cc3)no2)ccc[n+]1COP(=O)([O-])O
InChI	InChI=1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)

InChI Key

JQONJQKKVAHONF-UHFFFAOYSA-N

Smiles

Nc1c(-c2cc(Cc3ccc(COc4ccccn4)cc3)no2)ccc[n+]1COP(=O)([O-])O

InChI

InChI=1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)

Property Name	Value
Molecular Formula	C22H21N4O6P
Molecular Weight	468.41
AlogP	2.21
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	9.0
Polar Surface Area	147.64
Molecular species	ACID
Aromatic Rings	4.0
Heavy Atoms	33.0

Property Name

Value

Molecular Formula

C22H21N4O6P

Molecular Weight

468.41

AlogP

2.21

Hydrogen Bond Acceptor

8.0

Hydrogen Bond Donor

2.0

Number of Rotational Bond

9.0

Polar Surface Area

147.64

Molecular species

ACID

Aromatic Rings

4.0

Heavy Atoms

33.0

Mechanism of Action	Action	Reference
GPI-anchored wall transfer protein 1 inhibitor	INHIBITOR	PubMed

Mechanism of Action

Action

Reference

GPI-anchored wall transfer protein 1 inhibitor

INHIBITOR

PubMed

Resources	Reference
ChEMBL	CHEMBL4297591
DrugBank	DB15183
FDA SRS	1XQ871489P
PubChem	44123754

Resources

Reference

ChEMBL

DrugBank

FDA SRS

PubChem

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

FOSMANOGEPIX

Structure

Physicochemical Descriptors

Pharmacology

Cross References