DERENOFYLLINE

/static/temp/default.svg

Search structure


Synonyms	Derenofylline SLV-320 SLV320 Slv320
Status
Molecule Category	Free-form
UNII	O1Q96UZ63W

Structure


InChI Key	RBZNJGHIKXAKQE-UHFFFAOYSA-N
Smiles	OC1CCC(Nc2nc(-c3ccccc3)nc3[nH]ccc23)CC1
InChI	InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H20N4O
Molecular Weight	308.39
AlogP	3.34
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	3.0
Polar Surface Area	73.83
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	23.0

Pharmacology

Mechanism of Action	Action	Reference
Adenosine A1 receptor antagonist	ANTAGONIST	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Nucleotide-like receptor (family A GPCR) Adenosine receptor	-	-	-	1-501	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	-	-	1-398	-
Rattus norvegicus	-	-	-	2.51-501	-

Target Conservation


Protein: Adenosine A1 receptor Description: Adenosine receptor A1 Organism : Homo sapiens P30542 ENSG00000163485

Cross References

Resources	Reference
ChEMBL	CHEMBL592435
FDA SRS	O1Q96UZ63W
SureChEMBL	SCHEMBL2832387

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025