AZD3514

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Search structure


Synonyms	AZD-3514 Azd 3514 Azd3514 CS-1443
Status
Molecule Category	Free-form
UNII	127DSS8X7J
EPA CompTox	DTXSID80677133

Structure


InChI Key	JMEYDSHPKCSIJC-UHFFFAOYSA-N
Smiles	CC(=O)N1CCN(CCOc2ccc(C3CCN(C4=Nn5c(nnc5C(F)(F)F)CC4)CC3)cc2)CC1
InChI	InChI=1S/C25H32F3N7O2/c1-18(36)33-14-12-32(13-15-33)16-17-37-21-4-2-19(3-5-21)20-8-10-34(11-9-20)23-7-6-22-29-30-24(25(26,27)28)35(22)31-23/h2-5,20H,6-17H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H32F3N7O2
Molecular Weight	519.57
AlogP	2.83
Hydrogen Bond Acceptor	8.0
Number of Rotational Bond	5.0
Polar Surface Area	79.09
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Androgen Receptor modulator	MODULATOR	PubMed PubMed

Target Conservation


Protein: Androgen Receptor Description: Androgen receptor Organism : Homo sapiens P10275 ENSG00000169083

Cross References

Resources	Reference
ChEMBL	CHEMBL2346976
FDA SRS	127DSS8X7J
SureChEMBL	SCHEMBL3056463
ZINC	ZINC000101673084

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025