AEW-541

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Synonyms
Status
Molecule Category Free-form
UNII 97QB5037VR

Structure

InChI Key USVCWSAJUAARAL-MEMLXQNLSA-N
Smiles Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@H](N2CCC2)C1
InChI
InChI=1S/C26H27N5O/c27-25-24-23(19-8-4-9-22(12-19)32-16-18-6-2-1-3-7-18)15-31(26(24)29-17-28-25)21-13-20(14-21)30-10-5-11-30/h1-4,6-9,12,15,17,20-21H,5,10-11,13-14,16H2,(H2,27,28,29)/t20-,21-

Physicochemical Descriptors

Property Name Value
Molecular Formula C26H27N5O
Molecular Weight 425.54
AlogP 4.67
Hydrogen Bond Acceptor 6.0
Hydrogen Bond Donor 1.0
Number of Rotational Bond 6.0
Polar Surface Area 69.2
Molecular species BASE
Aromatic Rings 4.0
Heavy Atoms 32.0

Pharmacology

Mechanism of Action Action Reference
Insulin-like growth factor I receptor inhibitor INHIBITOR PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase InsR family
- 86-150 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Mus musculus
- 140-150 - - -

Target Conservation

Protein: Insulin-like growth factor I receptor
Description: Insulin-like growth factor 1 receptor
Organism : Homo sapiens
P08069 ENSG00000140443

Cross References

Resources Reference
ChEMBL CHEMBL551064
FDA SRS 97QB5037VR
PubChem 11476171
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