EcoDrugPlus


Synonyms	CGP-23339AE Pamidronate Pamidronic Acid Pamidronic acid Ribodroat
Status
Molecule Category	Free-form
ATC	M05BA03
UNII	OYY3447OMC
EPA CompTox	DTXSID4023414


InChI Key	WRUUGTRCQOWXEG-UHFFFAOYSA-N
Smiles	NCCC(O)(P(=O)(O)O)P(=O)(O)O
InChI	InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)

Property Name	Value
Molecular Formula	C3H11NO7P2
Molecular Weight	235.07
AlogP	-1.66
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	6.0
Number of Rotational Bond	4.0
Polar Surface Area	161.31
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	13.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Transferase	-	200-353.2	-	55.9-331.4	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	200-353.2	-	55.9-331.4	-
Leishmania major	-	-	-	180-190	-
Mus musculus	-	200	-	-	-

Resources	Reference
ChEBI	7903
ChEMBL	CHEMBL834
DrugBank	DB00282
DrugCentral	2048
FDA SRS	OYY3447OMC
Human Metabolome Database	HMDB0014427
Guide to Pharmacology	7259
KEGG	C07395
PDB	210
PharmGKB	PA450767
PubChem	4674
SureChEMBL	SCHEMBL18361
ZINC	ZINC000003812862

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

PAMIDRONIC ACID

Structure

Physicochemical Descriptors

Pharmacology

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