EcoDrugPlus


Synonyms	ATI-7505 Naronapride
Status
Molecule Category	Free-form
UNII	058896B00B

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SubStructure

Threshold (%) >= 70


InChI Key	VGDDOIZXGFJDRC-VJTSUQJLSA-N
Smiles	COc1cc(N)c(Cl)cc1C(=O)N[C@@H]1CCN(CCCCCC(=O)O[C@H]2CN3CCC2CC3)C[C@@H]1OC
InChI	InChI=1S/C27H41ClN4O5/c1-35-23-15-21(29)20(28)14-19(23)27(34)30-22-9-13-31(17-25(22)36-2)10-5-3-4-6-26(33)37-24-16-32-11-7-18(24)8-12-32/h14-15,18,22,24-25H,3-13,16-17,29H2,1-2H3,(H,30,34)/t22-,24+,25+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C27H41ClN4O5
Molecular Weight	537.1
AlogP	2.95
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	11.0
Polar Surface Area	106.36
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	37.0

Mechanism of Action	Action	Reference
Serotonin 4 (5-HT4) receptor agonist	AGONIST	PubMed

Target Conservation


Protein: Serotonin 4 (5-HT4) receptor Description: 5-hydroxytryptamine receptor 4 Organism : Homo sapiens Q13639 ENSG00000164270

Cross References

Resources	Reference
ChEMBL	CHEMBL2103858
DrugBank	DB05542
FDA SRS	058896B00B
PubChem	11237985
SureChEMBL	SCHEMBL731063

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

NARONAPRIDE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References