PROGLUMIDE

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC A02BX06
UNII EPL8W5565D
EPA CompTox DTXSID7023516

Structure

InChI Key DGMKFQYCZXERLX-UHFFFAOYSA-N
Smiles CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1
InChI
InChI=1S/C18H26N2O4/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H26N2O4
Molecular Weight 334.42
AlogP 2.3
Hydrogen Bond Acceptor 3.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 10.0
Polar Surface Area 86.71
Molecular species ACID
Aromatic Rings 1.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Cholecystokinin receptor antagonist ANTAGONIST PubMed PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides
- - - - 104.84-105.02
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Cricetulus griseus
- - - - 104.84-105.02

Target Conservation

Protein: Cholecystokinin receptor
Description: Cholecystokinin receptor type A
Organism : Homo sapiens
P32238 ENSG00000163394
Protein: Cholecystokinin receptor
Description: Gastrin/cholecystokinin type B receptor
Organism : Homo sapiens
P32239 ENSG00000110148

Related Entries

Cross References

Resources Reference
ChEBI 32058
ChEMBL CHEMBL316561
DrugBank DB13431
DrugCentral 2281
FDA SRS EPL8W5565D
Guide to Pharmacology 893
PubChem 4922
SureChEMBL SCHEMBL93339
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