XL-019

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Search structure


Synonyms	XL019 Xl-019
Status
Molecule Category	Free-form
UNII	4L1AM42NVA

Structure


InChI Key	ISOCDPQFIXDIMS-UHFFFAOYSA-N
Smiles	O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1
InChI	InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H28N6O2
Molecular Weight	444.54
AlogP	3.41
Hydrogen Bond Acceptor	7.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	91.41
Molecular species	BASE
Aromatic Rings	3.0
Heavy Atoms	33.0

Pharmacology

Mechanism of Action	Action	Reference
Tyrosine-protein kinase JAK2 inhibitor	INHIBITOR	PubMed PubMed

Target Conservation


Protein: Tyrosine-protein kinase JAK2 Description: Tyrosine-protein kinase JAK2 Organism : Homo sapiens O60674 ENSG00000096968

Cross References

Resources	Reference
ChEMBL	CHEMBL3545328
FDA SRS	4L1AM42NVA
PubChem	57990869
SureChEMBL	SCHEMBL4379072

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025