NIALAMIDE

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Search structure


Synonyms	NSC-124514 Nialamide Niamid
Status
Molecule Category	Free-form
ATC	N06AF02
UNII	T2Q0RYM725
EPA CompTox	DTXSID1023362

Structure


InChI Key	NOIIUHRQUVNIDD-UHFFFAOYSA-N
Smiles	O=C(CCNNC(=O)c1ccncc1)NCc1ccccc1
InChI	InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H18N4O2
Molecular Weight	298.35
AlogP	1.02
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	7.0
Polar Surface Area	83.12
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Monoamine oxidase inhibitor	INHIBITOR	PubMed PubMed PubMed PubMed

Target Conservation


Protein: Monoamine oxidase Description: Amine oxidase [flavin-containing] A Organism : Homo sapiens P21397 ENSG00000189221











Protein: Monoamine oxidase Description: Amine oxidase [flavin-containing] B Organism : Homo sapiens P27338 ENSG00000069535

Cross References

Resources	Reference
ChEBI	94510
ChEMBL	CHEMBL1256841
DrugBank	DB04820
DrugCentral	1907
FDA SRS	T2Q0RYM725
PubChem	4472
SureChEMBL	SCHEMBL49430
ZINC	ZINC000001713761

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025