CAMPHOR

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Synonyms	Camphor Camphor (natural) Camphor (synthetic) Camphor d-form Camphor laurel Camphor laurel whole Camphor tree whole Camphor whole Camphor, d- Camphor, dl- Camphor, racemic Camphora Camphora camphora Camphora officinalis whole Camphora tree Camphortree whole Camphorwood Cinnamomum camphora Cinnamomum camphora whole Cinnamonum camphora D-camphor Dextrocamphor Dl-camphor FEMA NO. 2230 FEMA NO. 4513 Gum camphor Karpura whole Laurus camphora NSC-755918 Natural camphor Synthetic camphor Trans-pi-oxocamphor
Status
Molecule Category	UNKNOWN
UNII	5TJD82A1ET
EPA CompTox	DTXSID4024721


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	DSSYKIVIOFKYAU-XCBNKYQSSA-N
Smiles	CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2
InChI	InChI=1S/C10H16O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7H,4-6H2,1-3H3/t7-,10+/m1/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H16O
Molecular Weight	152.24
AlogP	2.4
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	0.0
Number of Rotational Bond	0.0
Polar Surface Area	17.07
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	11.0

Assay Description	Organism	Bioactivity	Reference
Inhibition of COX2 at 100 uM by scintillation proximity assay	None	30.0 %
Antifeedant activity against adult Spodoptera littoralis fed on compound treated artificial diet by choice feeding assay	Spodoptera littoralis	50.0 microg/cm2
Antifeedant activity against adult Leptinotarsa decemlineata fed on compound treated potato foliage by choice feeding assay	Leptinotarsa decemlineata	50.0 microg/cm2
Antifungal activity against Rhizoctonia solani	Rhizoctonia solani	488.0 ug.mL-1
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	1.51 %		Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	Homo sapiens	4.08 %
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	6.446 %		SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate	Severe acute respiratory syndrome coronavirus 2	28.93 %
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.16 %		Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.14 %		Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.16 %		Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	Chlorocebus sabaeus	-0.14 %

Related Entries

Cross References

Resources	Reference
ChEBI	15396
ChEMBL	CHEMBL504760
DrugBank	DB01744
FDA SRS	5TJD82A1ET
Human Metabolome Database	HMDB0059838
PDB	CAM
SureChEMBL	SCHEMBL16069
ZINC	ZINC000000967520

CONTENTS

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).