MEBEVERINE HYDROCHLORIDE

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Search structure


Synonyms	CSAG-144 Colofac Colofac 100 Colofac ibs Colofac mr Fomac Mebeverine hcl Mebeverine hydrochloride NSC-169101
Status
Molecule Category	Salt-form
UNII	15VZ5AL4JN
EPA CompTox	DTXSID1045372

Structure


InChI Key	PLGQWYOULXPJRE-UHFFFAOYSA-N
Smiles	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1.Cl
InChI	InChI=1S/C25H35NO5.ClH/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5;/h9-14,18-19H,6-8,15-17H2,1-5H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C25H36ClNO5
Molecular Weight	466.02
AlogP	4.6
Hydrogen Bond Acceptor	6.0
Number of Rotational Bond	13.0
Polar Surface Area	57.23
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	31.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	89.99-111.98

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	89.99-111.98

Cross References

Resources	Reference
ChEMBL	CHEMBL1446650
FDA SRS	15VZ5AL4JN
PubChem	17683
SureChEMBL	SCHEMBL121977

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025