ZONAMPANEL

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Synonyms
Status
Molecule Category Free-form
UNII 9X33544ILS
EPA CompTox DTXSID50175232

Structure

InChI Key SPXYHZRWPRQLNS-UHFFFAOYSA-N
Smiles O=C(O)Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(-n3ccnc3)cc21
InChI
InChI=1S/C13H9N5O6/c19-11(20)5-17-8-4-9(16-2-1-14-6-16)10(18(23)24)3-7(8)15-12(21)13(17)22/h1-4,6H,5H2,(H,15,21)(H,19,20)

Physicochemical Descriptors

Property Name Value
Molecular Formula C13H9N5O6
Molecular Weight 331.24
AlogP -0.13
Hydrogen Bond Acceptor 8.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 4.0
Polar Surface Area 153.12
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 24.0

Pharmacology

Mechanism of Action Action Reference
Glutamate receptor ionotropic AMPA antagonist ANTAGONIST PubMed PubMed Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor AMPA receptor
- - - 62-62 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Rattus norvegicus
- - - 62-96 -

Target Conservation

Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 1
Organism : Homo sapiens
P42261 ENSG00000155511
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 2
Organism : Homo sapiens
P42262 ENSG00000120251
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 3
Organism : Homo sapiens
P42263 ENSG00000125675
Protein: Glutamate receptor ionotropic AMPA
Description: Glutamate receptor 4
Organism : Homo sapiens
P48058 ENSG00000152578

Cross References

Resources Reference
ChEMBL CHEMBL119625
FDA SRS 9X33544ILS
PubChem 9798437
SureChEMBL SCHEMBL678832
ZINC ZINC000001891930
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