ZONAMPANEL


Synonyms	YM 872 ANHYDROUS YM-872 YM-872 ANHYDROUS YM872 YM872 ANHYDROUS Ym 872 Zonampanel Zonampanel anhydrous Zonampanel monohydrate
Status
Molecule Category	UNKNOWN
UNII	9X33544ILS
EPA CompTox	DTXSID50175232


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	SPXYHZRWPRQLNS-UHFFFAOYSA-N
Smiles	O=C(O)Cn1c(=O)c(=O)[nH]c2cc([N+](=O)[O-])c(-n3ccnc3)cc21
InChI	InChI=1S/C13H9N5O6/c19-11(20)5-17-8-4-9(16-2-1-14-6-16)10(18(23)24)3-7(8)15-12(21)13(17)22/h1-4,6H,5H2,(H,15,21)(H,19,20)

Mechanism of Action	Action	Reference
Glutamate receptor ionotropic AMPA antagonist	ANTAGONIST	PubMed PubMed Other


Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 1 Organism : Homo sapiens P42261 ENSG00000155511











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 2 Organism : Homo sapiens P42262 ENSG00000120251











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 3 Organism : Homo sapiens P42263 ENSG00000125675











Protein: Glutamate receptor ionotropic AMPA Description: Glutamate receptor 4 Organism : Homo sapiens P48058 ENSG00000152578

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor AMPA receptor	-	-	-	62-62	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22 family of organic cation and anion transporters	-	3000	-	-	-

Assay Description	Organism	Bioactivity
Binding affinity for ionotropic glutamate receptor AMPA using [3H]AMPA as radioligand, bound to synaptic membranes prepared from rat cerebral cortex	None	62.0 nM
Displacement of [3H]AMPA (5 nM) from ionotropic glutamate receptor AMPA of rat cerebral cortex synaptic membrane preparation	Rattus norvegicus	62.0 nM
Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane	Rattus norvegicus	96.0 nM

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