None is not found in the database.

SEROTONIN


Synonyms	5-HT 5-Hydroxytryptamine Enteramine Serotonin Thrombotonin
Status
Molecule Category	Free-form
UNII	333DO1RDJY
EPA CompTox	DTXSID8075330


InChI Key	QZAYGJVTTNCVMB-UHFFFAOYSA-N
Smiles	NCCc1c[nH]c2ccc(O)cc12
InChI	InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

Property Name	Value
Molecular Formula	C10H12N2O
Molecular Weight	176.22
AlogP	1.37
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	2.0
Polar Surface Area	62.04
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	13.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	-	-	-	25.6-62.59
Ion channel Ligand-gated ion channel 5HT3 receptor	141-980	727	-	66-398.11	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Dopamine receptor	523	0.0003	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	0.07079-351	0.25-680	3.98	0.11-977.24	0-100
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	-	-	740-740	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC18 family of vesicular amine transporters	-	98	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	3-3	-	3	-
Canis lupus familiaris	210	0.0003	-	-	-
Cavia porcellus	5-43	3-5.2	-	100-230	-
Electrophorus electricus	-	-	-	-	62.59
Homo sapiens	0.07079-500	0.25-323	3.98	0.11-690	0-100
Macaca mulatta	-	-	-	35	-
Mus musculus	0.5248-980	5-680	-	150-500	-
Oryctolagus cuniculus	158.49-300	-	-	-	-
Rattus norvegicus	2.8-977.24	0.9-600	-	0.3-977.24	-
Saccharomyces cerevisiae	-	-	-	-	25.6
Sus scrofa	-	81	-	35	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	28790
ChEMBL	CHEMBL39
DrugBank	DB08839
FDA SRS	333DO1RDJY
Human Metabolome Database	HMDB0000259
Guide to Pharmacology	5
KEGG	C00780
PDB	SRO
PubChem	5202
SureChEMBL	SCHEMBL1495
ZINC	ZINC000000057058

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

SEROTONIN

Structure

Physicochemical Descriptors

Pharmacology

Related Entries

Cross References