TEPOTINIB HYDROCHLORIDE

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Search structure


Synonyms	MSC2156119J Msc2156119j Tepmetko Tepotinib hydrochloride
Status
Molecule Category	Salt-form
UNII	VY5YX2TQ1F

Structure


InChI Key	KZVOMLRKFJUTLK-UHFFFAOYSA-N
Smiles	CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1.Cl.O
InChI	InChI=1S/C29H28N6O2.ClH.H2O/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30;;/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3;1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C29H31ClN6O3
Molecular Weight	547.06
AlogP	4.01
Hydrogen Bond Acceptor	8.0
Number of Rotational Bond	7.0
Polar Surface Area	96.93
Molecular species	BASE
Aromatic Rings	4.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Hepatocyte growth factor receptor inhibitor	INHIBITOR	PMDA PubMed

Target Conservation


Protein: Hepatocyte growth factor receptor Description: Hepatocyte growth factor receptor Organism : Homo sapiens P08581 ENSG00000105976

Cross References

Resources	Reference
ChEMBL	CHEMBL4594292
FDA SRS	VY5YX2TQ1F
PubChem	46700774
SureChEMBL	SCHEMBL1296467

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025