DRINABANT

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Search structure


Synonyms	Ave1625 Drinabant
Status
Molecule Category	Free-form
UNII	61S98RLL5I
EPA CompTox	DTXSID50189455

Structure


InChI Key	IQQBRKLVEALROM-UHFFFAOYSA-N
Smiles	CS(=O)(=O)N(c1cc(F)cc(F)c1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1
InChI	InChI=1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H20Cl2F2N2O2S
Molecular Weight	497.39
AlogP	5.51
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	40.62
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	32.0

Pharmacology

Mechanism of Action	Action	Reference
Cannabinoid CB1 receptor antagonist	ANTAGONIST	PubMed PubMed Wikipedia

Target Conservation


Protein: Cannabinoid CB1 receptor Description: Cannabinoid receptor 1 Organism : Homo sapiens P21554 ENSG00000118432

Cross References

Resources	Reference
ChEMBL	CHEMBL3545166
FDA SRS	61S98RLL5I
PubChem	10278470
SureChEMBL	SCHEMBL684143
ZINC	ZINC000059299699

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025