PIPERAZINE

/static/temp/default.svg

Search structure


Synonyms	Antepar Ascalix Ectodyne Expelix Ins umuline rapide Piperazine Wormex
Status
Molecule Category	Free-form
ATC	P02CB01
UNII	1RTM4PAL0V
EPA CompTox	DTXSID1021164

Structure


InChI Key	GLUUGHFHXGJENI-UHFFFAOYSA-N
Smiles	C1CNCCN1
InChI	InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C4H10N2
Molecular Weight	86.14
AlogP	-0.82
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Polar Surface Area	24.06
Molecular species	BASE
Aromatic Rings	0.0
Heavy Atoms	6.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	77.78-102.08

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	77.78-102.08

Cross References

Resources	Reference
CAS NUMBER	110-85-0
ChEBI	28568
ChEMBL	CHEMBL1412
DrugBank	DB00592
DrugCentral	2188
FDA SRS	1RTM4PAL0V
Human Metabolome Database	HMDB0014730
KEGG	C07973
PDB	PZE
PharmGKB	PA450977
PubChem	4837
SureChEMBL	SCHEMBL238
ZINC	ZINC000005850277

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 23^rd March 2026