AMG-900

/static/temp/default.svg

Search structure


Synonyms	AMG900 Amg 900 Amg-900
Status
Molecule Category	Free-form
UNII	9R2G075611
EPA CompTox	DTXSID90241526

Structure


InChI Key	IVUGFMLRJOCGAS-UHFFFAOYSA-N
Smiles	Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1
InChI	InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C28H21N7OS
Molecular Weight	503.59
AlogP	6.64
Hydrogen Bond Acceptor	9.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	6.0
Polar Surface Area	111.73
Molecular species	NEUTRAL
Aromatic Rings	6.0
Heavy Atoms	37.0

Pharmacology

Mechanism of Action	Action	Reference
Serine/threonine-protein kinase Aurora inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family	-	1-5	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	1-5	-	-	-

Cross References

Resources	Reference
CAS NUMBER	945595-80-2
ChEMBL	CHEMBL2140408
FDA SRS	9R2G075611
Guide to Pharmacology	8060
PubChem	24856041
SureChEMBL	SCHEMBL503564
ZINC	ZINC000043208325

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026