PROXIBARBAL

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Search structure


Synonyms	Axeen Centralgol HH-184 Hydroxydial Ipronal Proxibarbal
Status
Molecule Category	Free-form
ATC	N05CA22
UNII	F97OMS297F

Structure


InChI Key	VNLMRPAWAMPLNZ-UHFFFAOYSA-N
Smiles	C=CCC1(CC(C)O)C(=O)NC(=O)NC1=O
InChI	InChI=1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C10H14N2O4
Molecular Weight	226.23
AlogP	-0.31
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	4.0
Polar Surface Area	95.5
Molecular species	NEUTRAL
Aromatic Rings	0.0
Heavy Atoms	16.0

Pharmacology

Mechanism of Action	Action	Reference
Diamine oxidase activator	ACTIVATOR	PubMed

Target Conservation


Protein: Diamine oxidase Description: Amiloride-sensitive amine oxidase [copper-containing] Organism : Homo sapiens P19801 ENSG00000002726












Protein: Monoamine oxidase A Description: Amine oxidase [flavin-containing] A Organism : Homo sapiens P21397 ENSG00000189221

Related Entries

Cross References

Resources	Reference
ChEBI	134928
ChEMBL	CHEMBL2105233
DrugBank	DB13253
DrugCentral	2322
FDA SRS	F97OMS297F
PubChem	17336
SureChEMBL	SCHEMBL715014

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025