LIDORESTAT

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Search structure


Synonyms	EML 676 EML-676 IDD 676 IDD-000676 IDD-000676-01 IDD-676 Lidorestat Lidorestat anhydrous Lindolrestat Lindorestat
Status
Molecule Category	Free-form
UNII	9Z74BD3QPP
EPA CompTox	DTXSID10215688

Structure


InChI Key	KYHVTMFADJNSGS-UHFFFAOYSA-N
Smiles	O=C(O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc21
InChI	InChI=1S/C18H11F3N2O2S/c19-11-6-12(20)18-17(16(11)21)22-14(26-18)5-9-7-23(8-15(24)25)13-4-2-1-3-10(9)13/h1-4,6-7H,5,8H2,(H,24,25)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H11F3N2O2S
Molecular Weight	376.36
AlogP	4.34
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	4.0
Polar Surface Area	55.12
Molecular species	ACID
Aromatic Rings	4.0
Heavy Atoms	26.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	5-5	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	5-5	-	-	-
Rattus norvegicus	-	5	-	-	77-100

Cross References

Resources	Reference
CAS NUMBER	653599-32-7
ChEMBL	CHEMBL363387
DrugBank	DB07063
FDA SRS	9Z74BD3QPP
Guide to Pharmacology	7411
PDB	3NA
PubChem	157838
SureChEMBL	SCHEMBL419032
ZINC	ZINC000000538652

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 23^rd March 2026