EcoDrugPlus


Synonyms	GDC-0919 IDO-IN-7 NLG-919 NLG919 Navoximod RG-6078 RG6078 RO-7077339 RO7077339 RO7077339-001
Status
Molecule Category	Free-form
UNII	926SHL95NC

Synonyms

GDC-0919

IDO-IN-7

NLG-919

NLG919

Navoximod

RG-6078

RG6078

RO-7077339

RO7077339

RO7077339-001

Status

Molecule Category

Free-form

UNII

926SHL95NC


InChI Key	YGACXVRLDHEXKY-WXRXAMBDSA-N
Smiles	O[C@H](C[C@H]1c2c(F)cccc2-c2cncn21)[C@H]1CC[C@H](O)CC1
InChI	InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11-,12-,15-,17+/m0/s1

InChI Key

YGACXVRLDHEXKY-WXRXAMBDSA-N

Smiles

O[C@H](C[C@H]1c2c(F)cccc2-c2cncn21)[C@H]1CC[C@H](O)CC1

InChI

InChI=1S/C18H21FN2O2/c19-14-3-1-2-13-16-9-20-10-21(16)15(18(13)14)8-17(23)11-4-6-12(22)7-5-11/h1-3,9-12,15,17,22-23H,4-8H2/t11-,12-,15-,17+/m0/s1

Property Name	Value
Molecular Formula	C18H21FN2O2
Molecular Weight	316.38
AlogP	2.89
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	58.28
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	23.0

Property Name

Value

Molecular Formula

C18H21FN2O2

Molecular Weight

316.38

AlogP

2.89

Hydrogen Bond Acceptor

4.0

Hydrogen Bond Donor

2.0

Number of Rotational Bond

3.0

Polar Surface Area

58.28

Molecular species

NEUTRAL

Aromatic Rings

2.0

Heavy Atoms

23.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	75-75	13-800	-	5.8	-

Targets

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Enzyme Oxidoreductase

75-75

13-800

5.8

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	75-75	13-800	-	5.8	-
Mus musculus	-	-	-	-	50-60

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Homo sapiens

75-75

13-800

5.8

Mus musculus

50-60

Resources	Reference
CAS NUMBER	1402837-78-8
ChEMBL	CHEMBL3989951
DrugBank	DB15439
FDA SRS	926SHL95NC
PDB	LKP
PubChem	70914230
SureChEMBL	SCHEMBL13469854

Resources

Reference

CAS NUMBER

ChEMBL

DrugBank

FDA SRS

PDB

PubChem

SureChEMBL

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 27^th July 2026

NAVOXIMOD

Structure

Physicochemical Descriptors

Pharmacology

Cross References