EcoDrugPlus


Synonyms	Camptothecin-20-o-propionate
Status
Molecule Category	Free-form
UNII	4S145C552U
EPA CompTox	DTXSID30173074

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Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	YCNIQYLWIPCLNY-QHCPKHFHSA-N
Smiles	CCC(=O)O[C@]1(CC)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1
InChI	InChI=1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H20N2O5
Molecular Weight	404.42
AlogP	3.04
Hydrogen Bond Acceptor	7.0
Number of Rotational Bond	3.0
Polar Surface Area	87.49
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	30.0

Mechanism of Action	Action	Reference
DNA topoisomerase I inhibitor	INHIBITOR	ClinicalTrials PubMed

Target Conservation


Protein: DNA topoisomerase I Description: DNA topoisomerase 1 Organism : Homo sapiens P11387 ENSG00000198900

Cross References

Resources	Reference
ChEMBL	CHEMBL124162
FDA SRS	4S145C552U
SureChEMBL	SCHEMBL1618775
ZINC	ZINC000003828515

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

CAMPTOTHECIN-20-O-PROPIONATE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References