GSK-1070916

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Search structure


Synonyms	GSK 1070916A GSK1070916 Gsk-1070916 Gsk-1070916a
Status
Molecule Category	Free-form
UNII	8VLB51V7HO
EPA CompTox	DTXSID70241403

Structure


InChI Key	QTBWCSQGBMPECM-UHFFFAOYSA-N
Smiles	CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1
InChI	InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C30H33N7O
Molecular Weight	507.64
AlogP	5.94
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	7.0
Polar Surface Area	82.08
Molecular species	BASE
Aromatic Rings	5.0
Heavy Atoms	38.0

Pharmacology

Mechanism of Action	Action	Reference
Serine/threonine-protein kinase Aurora-B inhibitor	INHIBITOR	PubMed PubMed
Serine/threonine-protein kinase Aurora-C inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Kinase Protein Kinase CAMK protein kinase group CAMK protein kinase CAMK1 family CAMK protein kinase QIK subfamily	-	70	-	-	-
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family	-	3.162-32	-	0.38-492	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase FGFR family	-	76	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Tie family	-	59	-	-	-
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase VEGFR family	-	42-74	-	-	-
Other nuclear protein	-	3.162-3.2	-	0.38-1.5	-
Unclassified protein	-	-	-	490	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	7-7	3.162-6.5	-	0.38-490	-

Target Conservation


Protein: Serine/threonine-protein kinase Aurora-B Description: Aurora kinase B Organism : Homo sapiens Q96GD4 ENSG00000178999











Protein: Serine/threonine-protein kinase Aurora-C Description: Aurora kinase C Organism : Homo sapiens Q9UQB9 ENSG00000105146

Cross References

Resources	Reference
CAS NUMBER	942918-07-2
ChEBI	91362
ChEMBL	CHEMBL1090479
FDA SRS	8VLB51V7HO
Guide to Pharmacology	8358
PubChem	46885626
SureChEMBL	SCHEMBL4305006
ZINC	ZINC000043170519

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 27^th July 2026