EcoDrugPlus


Synonyms	Catabex Dipropizine Ditustat Dopropizin Dropropizine Katril Larylin NSC-757820 Ribex Tussilex U.C.B.-1967 UCB 1967 UCB-1967
Status
Molecule Category	Free-form
ATC	R05DB19
UNII	U0K8WHL37U
EPA CompTox	DTXSID0045624


InChI Key	PTVWPYVOOKLBCG-UHFFFAOYSA-N
Smiles	OCC(O)CN1CCN(c2ccccc2)CC1
InChI	InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

Property Name	Value
Molecular Formula	C13H20N2O2
Molecular Weight	236.32
AlogP	0.16
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	46.94
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	17.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	71.05-96.03

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	71.05-96.03

Resources	Reference
ChEBI	93837
ChEMBL	CHEMBL151445
DrugBank	DB13785
DrugCentral	967
FDA SRS	U0K8WHL37U
PubChem	3169
SureChEMBL	SCHEMBL93975

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

DROPROPIZINE

Structure

Physicochemical Descriptors

Pharmacology

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