AZD-8186

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Synonyms
Status
Molecule Category Free-form
UNII AIQ4OWD0RA
EPA CompTox DTXSID001352155

Structure

InChI Key LMJFJIDLEAWOQJ-CQSZACIVSA-N
Smiles C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12
InChI
InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

Pharmacology

Mechanism of Action Action Reference
PI3-kinase p110-beta subunit inhibitor INHIBITOR PubMed
PI3-kinase p110-delta subunit inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Transferase
- 3-752 - - -
Enzyme
- 3-752 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 3-752 - - -

Target Conservation

Protein: PI3-kinase p110-delta subunit
Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Organism : Homo sapiens
O00329 ENSG00000171608
Protein: PI3-kinase p110-beta subunit
Description: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Organism : Homo sapiens
P42338 ENSG00000051382

Cross References

Resources Reference
CAS NUMBER 1627494-13-6
ChEMBL CHEMBL3545424
FDA SRS AIQ4OWD0RA
PubChem 52913813
CONTENTS