ENARODUSTAT

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Search structure


Synonyms	Enarodustat JTZ-951 Jtz-951
Status
Molecule Category	Free-form
UNII	JSK7TUA223

Structure


InChI Key	NALAUGMPMIVAOW-UHFFFAOYSA-N
Smiles	O=C(O)CNC(=O)c1c(O)cc(CCc2ccccc2)n2ncnc12
InChI	InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10,22H,6-7,9H2,(H,18,25)(H,23,24)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H16N4O4
Molecular Weight	340.34
AlogP	1.03
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	116.82
Molecular species	ACID
Aromatic Rings	3.0
Heavy Atoms	25.0

Pharmacology

Mechanism of Action	Action	Reference
Egl nine homolog 1 inhibitor	INHIBITOR	PubMed

Target Conservation


Protein: Egl nine homolog 1 Description: Egl nine homolog 1 Organism : Homo sapiens Q9GZT9 ENSG00000135766

Cross References

Resources	Reference
ChEMBL	CHEMBL4297619
DrugBank	DB14985
FDA SRS	JSK7TUA223
PubChem	50899324
SureChEMBL	SCHEMBL1481440

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025