EcoDrugPlus


Synonyms	ANO-1020 L-nmma acetate Ng-methylarginine acetate Ng-monomethyl-l-arginine acetate Targinine acetate Tilarginine acetate
Status
Molecule Category	Salt-form
UNII	2FL3530AF2
EPA CompTox	DTXSID7045780

Synonyms

ANO-1020

L-nmma acetate

Ng-methylarginine acetate

Ng-monomethyl-l-arginine acetate

Targinine acetate

Tilarginine acetate

Status

Molecule Category

Salt-form

UNII

2FL3530AF2

EPA CompTox

DTXSID7045780


InChI Key	IKPNWIGTWUZCKM-JEDNCBNOSA-N
Smiles	CC(=O)O.CNC(=N)NCCC[C@H](N)C(=O)O
InChI	InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

InChI Key

IKPNWIGTWUZCKM-JEDNCBNOSA-N

Smiles

CC(=O)O.CNC(=N)NCCC[C@H](N)C(=O)O

InChI

InChI=1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

Property Name	Value
Molecular Formula	C9H20N4O4
Molecular Weight	248.28
AlogP	-1.08
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	5.0
Number of Rotational Bond	5.0
Polar Surface Area	111.23
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	13.0

Property Name

Value

Molecular Formula

C9H20N4O4

Molecular Weight

248.28

AlogP

-1.08

Hydrogen Bond Acceptor

3.0

Hydrogen Bond Donor

5.0

Number of Rotational Bond

5.0

Polar Surface Area

111.23

Molecular species

ZWITTERION

Aromatic Rings

0.0

Heavy Atoms

13.0

Mechanism of Action	Action	Reference
Nitric oxide synthase inhibitor	INHIBITOR	PubMed PubMed PubMed

Mechanism of Action

Action

Reference

Nitric oxide synthase inhibitor

INHIBITOR

PubMed PubMed PubMed

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Mus musculus	-	-	-	-	22.79-58.16

EC50(nM)

IC50(nM)

Kd(nM)

Ki(nM)

Inhibition(%)

Mus musculus

22.79-58.16

Resources	Reference
ChEMBL	CHEMBL1256175
FDA SRS	2FL3530AF2
PubChem	135242
SureChEMBL	SCHEMBL1321022

Resources

Reference

ChEMBL

FDA SRS

PubChem

SureChEMBL

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

TILARGININE ACETATE

Structure

Physicochemical Descriptors

Pharmacology

Cross References