CP-195543


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	NZQDWKCNBOELAI-KSFYIVLOSA-N
Smiles	O=C(O)c1ccc(C(F)(F)F)cc1-c1ccc2c(c1)OC[C@H](Cc1ccccc1)[C@H]2O
InChI	InChI=1S/C24H19F3O4/c25-24(26,27)17-7-9-18(23(29)30)20(12-17)15-6-8-19-21(11-15)31-13-16(22(19)28)10-14-4-2-1-3-5-14/h1-9,11-12,16,22,28H,10,13H2,(H,29,30)/t16-,22+/m0/s1

Mechanism of Action	Action	Reference
Leukotriene B4 receptor antagonist	ANTAGONIST	PubMed PubMed


Protein: Leukotriene B4 receptor Description: Leukotriene B4 receptor 1 Organism : Homo sapiens Q15722 ENSG00000213903









Protein: Leukotriene B4 receptor Description: Leukotriene B4 receptor 2 Organism : Homo sapiens Q9NPC1 ENSG00000213906

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Leukotriene receptor	-	2-660	-	-	-

Assay Description	Organism	Bioactivity
Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils	None	280.0 nM
Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.	None	2.0 nM	Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.	None	2.4 nM	Ability to inhibit LTB4-induced chemotaxis of isolated human neutrophils.	None	7.0 nM
Ability to inhibit LTB4-induced CD11b up-regulation on isolated human neutrophils in whole blood	None	660.0 nM
Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.	None	56.0 nM	Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.	None	6.8 nM	Ability to inhibit LTB4 binding to LTB receptors on isolated human neutrophils.	None	13.0 nM

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