MSC-2363318A

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Synonyms
Status
Molecule Category Free-form
UNII 0DXG50I4WD

Structure

InChI Key HXAUJHZZPCBFPN-QGZVFWFLSA-N
Smiles NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(C(F)(F)F)c3)ncnc12
InChI
InChI=1S/C21H19ClF3N5O/c22-16-6-5-12(9-15(16)21(23,24)25)17(10-30-7-2-8-30)29-20-14-4-1-3-13(19(26)31)18(14)27-11-28-20/h1,3-6,9,11,17H,2,7-8,10H2,(H2,26,31)(H,27,28,29)/t17-/m1/s1

Pharmacology

Mechanism of Action Action Reference
Ribosomal protein S6 kinase (P70S6K) inhibitor INHIBITOR Other
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase AGC protein kinase group AGC protein kinase AKT family
- 4 - - -
Enzyme Kinase Protein Kinase Other protein kinase group Other protein kinase AUR family
- 170 - - -
Other nuclear protein
- 170 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 1.1-170 - - -

Target Conservation

Protein: Serine/threonine-protein kinase AKT
Description: RAC-alpha serine/threonine-protein kinase
Organism : Homo sapiens
P31749 ENSG00000142208
Protein: Serine/threonine-protein kinase AKT3
Description: RAC-gamma serine/threonine-protein kinase
Organism : Homo sapiens
Q9Y243 ENSG00000117020

Cross References

Resources Reference
ChEMBL CHEMBL3545003
FDA SRS 0DXG50I4WD
CONTENTS