VIDUPIPRANT


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	PFWVGKROPKKEDW-UHFFFAOYSA-N
Smiles	CC(C)(C)NC(=O)c1ccc(Oc2cc(F)c(CC(=O)O)cc2Cl)c(NS(=O)(=O)c2ccc(C3CC3)cc2Cl)c1
InChI	InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)

Mechanism of Action	Action	Reference
G protein-coupled receptor 44 antagonist	ANTAGONIST	PubMed


Protein: Prostanoid DP receptor Description: Prostaglandin D2 receptor Organism : Homo sapiens Q13258 ENSG00000168229











Protein: G protein-coupled receptor 44 Description: Prostaglandin D2 receptor 2 Organism : Homo sapiens Q9Y5Y4 ENSG00000183134

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C8	-	5400	-	1100-6000	-
Enzyme Protease Cysteine protease Cysteine protease CA clan Cysteine protease C2 family	-	7500	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor	-	3-8	-	-	-

Assay Description	Organism	Bioactivity
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin	Homo sapiens	3.0 nM
Displacement of [3H]-PGD2 from human CRTH2 receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma	Homo sapiens	8.0 nM
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 0.5% bovine serum albumin	Homo sapiens	4.0 nM
Displacement of [3H]-PGD2 from human Prostanoid DP receptor expressed in human HEK293 cells by scintillation counter in presence of 50% human plasma	Homo sapiens	35.0 nM

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