EcoDrugPlus


Synonyms	Medazepam Nobrium Pamnace
Status
Molecule Category	Free-form
ATC	N05BA03
UNII	P0J3387W3S
EPA CompTox	DTXSID1048708


InChI Key	YLCXGBZIZBEVPZ-UHFFFAOYSA-N
Smiles	CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21
InChI	InChI=1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15(14)19/h2-8,11H,9-10H2,1H3

Property Name	Value
Molecular Formula	C16H15ClN2
Molecular Weight	270.76
AlogP	3.63
Hydrogen Bond Acceptor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	15.6
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	19.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Ligand-gated ion channel GABA-A receptor	-	-	-	528	-

Resources	Reference
ChEBI	31807
ChEMBL	CHEMBL28333
DrugBank	DB13437
DrugCentral	1654
FDA SRS	P0J3387W3S
PubChem	4041
SureChEMBL	SCHEMBL18472
ZINC	ZINC000000001659

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MEDAZEPAM

Structure

Physicochemical Descriptors

Pharmacology

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